The film starts with two young American men, David Kessler (played by Naughton) and Jack Goodman (played by Dunne), on a backpacking holiday in England. Following an awkwardly tense visit to a village pub, the two men venture deep into the moors at night. They are attacked by a werewolf, which results in Jack's death and David being taken to a London hospital. Through apparitions of his dead friend and disturbing dream sequences, David becomes informed that he is a werewolf and will transform at the next full moon.

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